DHCR7 and Smith-Lemli-Opitz syndrome: Namely, the observed differences in the HYZ-altered post-lanosterol biochemical profile across the Dhcr7-deficient Neuro2a cells, Dhcr7T93M/T93M mouse neurons and glial cells, and human dermal fibroblasts from SLOS patients are surprising, as all four of these in vitro systems use the same sterol biosynthesis machinery.