In primary biliary cholangitis (PBC), macrophage caspase-10 has a greater cleavage capacity than caspase-8, with an increased ability to form complexes with RIPK1 and FADD, which can better cleave RIPK1 and inhibit necroptosis, and caspase-10 knockout macrophages are more likely to trigger pyroptosis and necroptosis [137] (Figure 1A and Figure 2A,B). The gene discussed is CASP8; the disease is primary biliary cholangitis.