IL-17RB is a specific component of the receptor for IL-17E, also known as IL-25, a major Th2 response mediator.86 iNKT cells have been shown to play a pathologic role in asthma and airway diseases in mouse models,87–89 and the impact of the lack of IL17RB expression in human iNKT cells on such diseases remains unknown. This evidence concerns the gene IL25 and asthma.