,34,88,89 The ability of ATOH1 to regulate neuronal fate determination and Notch ligands (DLL1, DLL3, and DLL4) in mice25 mirrors the activity of ASCL1 in SCLC59,82; in CDX17P, ATOH1 depletion increased expression of non-NE and cell adhesion genes, invoking a similar role of ATOH1 in NE fate determination in SCLC (Figure S4). Here, DLL3 is linked to small cell lung carcinoma.