To interpret the observed growth delay, we examined persistence of ATOH1 KD throughout the experiment by performing IHC for ATOH1 and GFP in resected s.c. tumors (mean tumor volume and time from implant: 603 ± 54 mm3, 44 ± 5 days ShRen +DOX; 552 ± 48 mm3, 70 ± 13 days ShATOH1 +DOX) (Figure 6B). Here, ATOH1 is linked to neoplasm.