MYCL amplification was also observed in ATOH1-expressing SCLC cell lines44 (HCC33 CN ratio ∼5 and CORL24 CN ratio ∼2) and PDXs (LX424/443),33 and all ATOH1 preclinical models expressed some of the highest reported levels of MYCL (Figures S1F and S1G). This evidence concerns the gene ATOH1 and small cell lung carcinoma.