A possible relationship between allergy-mediated MC activation and ASD has been hypothesized, supported by evidence that neuroinflammation-related cytokines/chemokines, such as interleukine-1β (IL-1β), IL-8 (CXCL8), and tumor necrosis factor α (TNF-α), are widely correlated with the development of ASD [103]. The gene discussed is CXCL8; the disease is allergic disease.