Also, decreased activity of Cu/Zn-SOD in the parietal cortex and cerebellum decreased oxidized glutathione (GSSG) levels in the caudate [14]; normal Mn-SOD activity in the parietal cortex and cerebellum [10] and normal levels of reduced glutathione (GSH) in the substantia nigra compacta (SNc), caudate, and cerebral cortex [14] have been shown in HD patients. Here, SOD2 is linked to Huntington disease.