A meta-analysis of studies on blood oxidative markers (combining results of plasma, serum, and erythrocytes), involving 375 HD patients and 447 HCs from 12 studies, showed an increase in lipid peroxidation markers and OH8dG concentrations and in GPx activity, a decrease in GSH levels, and similar SOD activity in HD patients compared to HCs [48]. This evidence concerns the gene SOD1 and Huntington disease.