The elevation of proliferator-activated receptor-gamma coactivator-1α (PGC-1α) and increased levels of ROS scavenging enzymes, such as catalase, copper- or zinc-containing superoxide dismutase (CuZnSOD or SOD1), and magnesium SOD, were found to be elevated in dry AMD eyes as a defense mechanism against the increased level of ROS [82,83,84]. Here, SOD1 is linked to dry age related macular degeneration.