WDR1 and familial pancreatic carcinoma: In pancreatic cancer, exosome-derived T[33]a has been found to promote liver metastasis by upregulating WDR1 gene (WD repeat-containing protein 1), which interacts with actin, activating hepatic stellate cells and mediating the infiltration of myeloid-derived suppressor cells to form pre-metastatic niches [33].