Previously, CaSR signaling has been implicated in the proliferative and remodeling processes of diseases, such as asthma [24], cardiac fibrosis [22], pulmonary arterial hypertension (PAH) [34], and chronic obstructive pulmonary disease (COPD) [35], some of which are common IPF comorbidities [2,36,37]. Here, CASR is linked to chronic obstructive pulmonary disease.