A few studies have suggested that AQP5 is involved in promoting epithelial-to-mesenchymal transition (EMT), a key step in cancer metastasis [19,26], and that transforming growth factor-β (TGF-β)-induced EMT modulates AQP3 expression supporting tumor invasion and the establishment of metastatic niches [27]. This evidence concerns the gene AQP5 and neoplasm.