IL18 and systemic lupus erythematosus: Moreover, multiple inflammatory mediators including IL-1β, IL-6, IL-18, CCL2, CCL3, CCL4, CCL5, CXCL9, and CXCL10 were reduced in the kidneys of Fli-1 heterozygote knockout mice with lupus [11,14,20,30,31] (Figure 3).