Previous studies have shown that Fli-1 is a positive regulator of CCL2, CCL3, CCL4, CCL5, CXCL9, and CXCL10 in the kidneys of Fli-1 heterozygote knockout mice with lupus and CXCL5 in dermal small vessels from Fli-1 knockout mice [19,30,31,32]. This evidence concerns the gene FLI1 and systemic lupus erythematosus.