In addition, numerous studies have confirmed that inflammatory mediators including IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-33, CCL2, Chemerin, TNFα, and IFNγ were enhanced in skins from SSc mice when Fli-1 was knocked down [23,24,25,39,53]. Here, IL4 is linked to systemic sclerosis.