In vitro, validation experiments performed on glioblastoma cell line GSC-0827 expressing high levels of EFR3B (EFR3Bhigh) and glioblastoma GSC-0131 cell line with trace expression of EFR3B (EFR3Blow) confirmed the compensatory relationship between EFR3A and EFR3B. This evidence concerns the gene EFR3B and glioblastoma.