TM6SF2 and metabolic dysfunction-associated steatotic liver disease: For example, variations in genes related to hepatic lipid metabolism, such as patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7), and glucokinase regulatory protein (GCKR), are associated with increased susceptibility to MASLD [34].