A beneficial anti-inflammatory effect of MPO is demonstrated in experimental lupus nephritis [44] and experimental autoimmune encephalomyelitis [45] where MPO-mediated suppression of pathogenic T cells overrides their harmful effects, as well as in LPS-, zymosan-, or non-viable Candida albicans-induced lung inflammation [46,47,48] and a sepsis model [49], where inflammation was more intensive in MPO-KO compared to wild-type mice. Here, MPO is linked to experimental autoimmune encephalomyelitis.