TRAF6 serves as a key hub for several breast cancer-driver signal transduction pathways, including PI3K/AKT/mTOR, Toll-like receptor (TLR), mitogen-activated protein kinase (MAPK), and Ras/Src Family Kinases, with downstream effects on NFκB and AP-1 signaling (66, , –69). The gene discussed is NFKB1; the disease is breast carcinoma.