TP53 and Cowden disease: Among others, targeted genes were enriched in pathways related to signal transduction (e.g. MAPK, Hippo, TNF, p53, PI3K-Akt, Wnt, TGF-beta, JAK-STAT and the Hedgehog signaling pathway), immune system (T-cell receptor signaling pathway, IL-17 signaling pathway, NOD-like receptor signaling pathway), cellular community (adherens junction, focal adhesion, tight junction, gap junction), apoptosis or bacterial invasion of epithelial cells, which are relevant for CD pathogenesis.