ACHE and dementia: Older adults with MCI and dementia face a broad array of challenges, including cognitive deficits, physical functional impairments, emotional disturbances, etc. Despite this, current pharmacological treatments for dementia, such as acetylcholinesterase inhibitors like donepezil and memantine, offer only modest symptomatic relief and do not halt disease progression, with safety concerns and limited efficacy remaining significant challenges [10].