With 1μg/ml CRP-XL alone, the inhibition of PAC-1 by 10 nmol/l PGI2 in those with advanced insulin resistance was significantly reduced compared with those with normal insulin sensitivity (28 ± 9% vs 52 ± 2% p<0.001), which was also evident with higher PGI2 concentration (Fig. 4e). Here, INS is linked to Insulin resistance.