INS and type 1 diabetes mellitus: Within the type 1 diabetes group, those with advanced insulin resistance (eGDR<6 mg kg−1 min−1) showed increased platelet activation compared with individuals with normal insulin sensitivity (eGDR>8 mg kg−1 min−1) with single agonist stimulation CD62P expression (29,167 ± 2177 vs 22,829 ± 2535, p<0.001 and PAC-1 19,339 ± 11,749 and 5187 ± 2872, p=0.02).