IFNA1 and type 1 diabetes mellitus: T1 IFNs are implicated in the induction of T1D in human patients and rodent models (Ferreira et al., 2014; Kallionpää et al., 2014), and in APECED patients, the anti-IFNα autoantibodies were associated with the protection against T1D development, suggesting their beneficial role in the disease (Meyer et al., 2016).