The fact that the novel miRNAs target genes such as EGF, NTRK3, ADRA1D, AVPR1A, ADCY1, ADRA1B, ADRA1A, MYLK3, MYLK4, GNAL, PLCE1, NOS1, PLCB1, and FGF10 may disrupt the calcium homeostasis, leading to modified signaling in the tumor microenvironment (Figure S1E). This evidence concerns the gene ADRA1D and neoplasm.