Adiponectin, a key adipocytokine, plays a role as a tumor suppressor by phosphorylating AMPK, downregulating MAPK, JAK/STAT, mTOR, and Wnt/β‐catenin pathways [64, 65], inhibiting metastases, and reversing epithelial‐mesenchymal transition [66]. This evidence concerns the gene PRKAA2 and neoplasm.