The fact that the novel miRNAs target genes such as EGF, NTRK3, ADRA1D, AVPR1A, ADCY1, ADRA1B, ADRA1A, MYLK3, MYLK4, GNAL, PLCE1, NOS1, PLCB1, and FGF10 may disrupt the calcium homeostasis, leading to modified signaling in the tumor microenvironment (Figure S1E). The gene discussed is NOS1; the disease is neoplasm.