Although the genes in (PRKAA2, GNG7, MYL3, NOS1, ADCY1, PLCB1, MYLK3, and MYLK4) the apelin/APJ signaling axis are found to be downregulated and might not be considered responsible in cdRCC progression, downregulation of GNG7 tells a different story due to its tumor‐suppressive activity (Figure S1C). This evidence concerns the gene APLN and neoplasm.