The RANK/RANKL/OPG pathway is central to the vicious cycle of bone metastasis and metastatic fractures: as tumor cells invade the bone, they disrupt normal bone homeostasis by increasing RANKL expression, which in turn enhances osteoclast‐mediated bone destruction; this not only facilitates the growth of the metastatic tumor within the bone but also leads to the deterioration of bone integrity, making it prone to fractures even under normal stress [93]. This evidence concerns the gene TNFSF11 and neoplasm.