Here, we show that JNK signaling is increased in prostate cancer polyaneuploid cells, and human CIC has been shown to be a tumor suppressor in prostate cancer (Gupta et al., 2022; Seim et al., 2017), suggesting that the Drosophila AG recapitulates key signaling features of the human cancer, despite the postmitotic state of the fly prostate-like cells. The gene discussed is MAPK8; the disease is prostate carcinoma.