In particular, we observed significant overlap with a gene expression signature from the Drosophila metastatic tumor model of oncogenic Ras combined with the loss of epithelial polarity through loss of the Scribble (Scrib) protein (RasV12,scrib−/− mutant) (Fig. 4C) (Atkins et al., 2016; Kulshammer et al., 2015) and wound healing gene expression profiles (Khan et al., 2017) (Table S5). Here, SCRIB is linked to metastatic neoplasm.