ERG and Familial prostate cancer: The upregulation of Drosophila Ets21C in the AG in response to oncogenic signaling could be particularly significant, considering its homology to the human ERG gene and other ETS transcription factors, known for their involvement in prostate cancer (Adamo and Ladomery, 2016; Nicholas et al., 2019; Qian et al., 2022; Tomlins et al., 2005).