PRKAA1 and neoplasm: A series of drugs, such as 13-methyl-palmatrubine (13MP) derived from the flower of Crotalaria juncea (116), β-caryophyllene (117), hydroxychloroquine (118), and birch bark acid (119), have been found to regulate the polarization state of TAMs by modulating signaling pathways such as the AMPKα1/STING, mTOR, PI3K/AKT, and JAK/STAT3 pathways, facilitating the transition from the tumor-promoting M2 phenotype to the antitumor M1 phenotype and thereby inhibiting lung cancer growth and progression.