Studies have shown that conditional deletion of E-cadherin or the expression of dominant-negative E-cadherin leads to weakened intercellular adhesion among cancer cells and induces vascular invasion and tumor growth through the upregulation of VEGF-A and VEGF-C mediated by β-catenin, thereby inducing micrometastasis in lung adenocarcinoma (53). This evidence concerns the gene CDH1 and lung adenocarcinoma.