A group of genes, including collagen type I alpha 1 (COL1A1), fibronectin 1 (FN1), laminin subunit gamma 2 (LAMC2), periostin (POSTN), transforming growth factor beta induced (TGFBI), are involved in extracellular mesenchymal organization and affect tumor behavior, akin to our findings. Here, COL1A1 is linked to neoplasm.