Considering that there is no exclusive marker for either subset, after referring to previous studies (44), we used SMA and PDGFRA to label myoCAF and iCAF, respectively, and immunohistochemical staining showed an abundant presence of myoCAFs in both groups, while iCAFs were relatively scarce and primarily located at the infiltrating leading edge of the tumor in LNM PTMC (Figure 8B). This evidence concerns the gene PDGFRA and neoplasm.