SNPs in genes involved with syndromes were previously associated with a variety of facial measurements, for example, genes such as FGFR1 (e.g., Pfeiffer syndrome and Kallmann syndrome) (3), IRF6 (e.g., Van der Woude syndrome) (5), and RUNX2 (e.g., cleidocranial dysplasia syndrome) (4). This evidence concerns the gene IRF6 and van der Woude syndrome.