SNPs in genes involved with syndromes were previously associated with a variety of facial measurements, for example, genes such as FGFR1 (e.g., Pfeiffer syndrome and Kallmann syndrome) (3), IRF6 (e.g., Van der Woude syndrome) (5), and RUNX2 (e.g., cleidocranial dysplasia syndrome) (4). The gene discussed is RUNX2; the disease is van der Woude syndrome.