This study is based on our previous findings that circELMOD3 expression is significantly downregulated in HCC tissues compared with controls, and it has the potential to be a highly effective diagnostic marker for liquid biopsy in HCC patients, as well as to inhibit HCC progression through miR-6864-5p/TRIM13/p53 signaling pathway (Lai, et al., 2023), The rapid development of bioinformatics allows its wide application in life science research. This evidence concerns the gene TP53 and hepatocellular carcinoma.