Furthermore, research showed that miR-3677-3p binds to FBXO31 and inhibit its expression in hepatitis B-associated hepatocellular carcinoma, this inhibition causes FOXM1 to be less ubiquitinated and degraded, which in turn encourages the growth of HCC and sorafenib resistance (He et al., 2023a). This evidence concerns the gene FBXO31 and hepatocellular carcinoma.