We identified 25 genome-wide significant loci for CRC and colon polyps, including three novel loci in East Asian populations: BET1L (rs12226698, 11p15.5), OAS1 (rs2525858, 12q24.13), and BMP2 (rs4813802, 20p12.3). The gene discussed is OAS1; the disease is polyp of colon.