In this analysis of CRC and colon polyps, we identified 25 genome-wide significant loci (Supplementary Table S2), including three novel loci in East Asian populations: rs12226698 at 11p15.5 (BET1L), rs2525858 at 12q24.13 (OAS1), and rs4813802 at 20p12.3 (BMP2). Here, OAS1 is linked to colon inflammatory polyp.