AKT1 and prion disease: The integrated analysis of pathways enriched by network pharmacology and metabolomics showed that there were eight metabolic pathways in network pharmacology and metabolomics, which were the PI3K-Akt signaling pathway, longevity regulating pathway, regulation of lipolysis in adipocytes, pathways of neurogenesis in multiple diseases, FOXO signaling pathway, prion disease, arachidonic acid metabolism, and central carbon metabolism in cancer (Figure 8).