When MM cells bind to bone marrow stromal cells (BMSCs), the activation of NF-κB influences the production of IL-6 and vascular endothelial growth factors, thereby facilitating the proliferation of MM cells (Mitsiades et al., 2006; Karin, 2006; Rajkumar and Kumar, 2020). Here, NFKB1 is linked to Miyoshi myopathy.