PNLIP and B-cell chronic lymphocytic leukemia: Marin and Mansilla (2006) studied the effects of PTL on inducing apoptosis and cytotoxicity in B-CLL cells in vitro. The study found that PTL effectively triggers apoptosis and exhibits potent cytotoxic effects specifically on B-CLL cells. Notably, it had little to no effect on normal peripheral blood mononuclear cells (PBMCs). This suggests that PTL may represent a promising therapeutic strategy for B-CLL (Marin and Mansilla, 2006).