A large number of ROS free radicals accumulate in cells for the activation of ERS and UPR, triggering oxidative stress response, triggering inflammation, and activating protein kinase R-like ER kinase (PERK)/C/EBP homologous protein (CHOP)/Caspase-12 and other signaling pathways, which become the basis of the pathogenesis of DKD (Ruiqiong et al., 2020). Here, DDIT3 is linked to diabetic kidney disease.