It has been reported that HG accelerates the occurrence and development of DKD by causing cell damage, releasing pro-inflammatory mediators such as adhesion molecules, chemokines such as tumor necrosis factor α (TNF-α) and interleukin-1β (IL-1β), which damage the kidney and promote the damage-related molecular pattern of fibrosis (Jung and Yoo, 2022). The gene discussed is TNF; the disease is diabetic kidney disease.