In ER+ breast cancer, the modulation of the PI3K-Akt and Wnt signaling pathways by m6A-SNPs related genes like FILIP1L and TOM1L1 is particularly compelling, given the established role of these pathways in promoting estrogen receptor signaling and cellular proliferation (Alves and Ditzel, 2023). The gene discussed is ESR1; the disease is breast carcinoma.