For the association analysis, 30 DEGs and DEPs in the third quadrant of PCVL258-infected mice at 7 dpi were enriched in KEGG pathways involved in protein processing in endoplasmic reticulum, complement and coagulation cascades, Staphylococcus aureus infection, phenylalanine metabolism, tyrosine metabolism, cocaine addiction, axon regeneration, tryptophan metabolism, amphetamine addiction, thyroid hormone synthesis, and prion diseases. Here, TG is linked to cocaine dependence.