Activation of NOTCH1 in myocardial cells is closely related to myocardial injury repair (19), and binding of NOTCH1 signaling proteins to Jagged1 reduces fibrotic tissue proliferation, increases microvascular density, and inhibits cardiac endothelial-mesenchymal transition (EMT), thereby preventing myocardial fibrosis (20). The gene discussed is JAG1; the disease is Myocardial fibrosis.