NOTCH1 and Myocardial fibrosis: Activation of NOTCH1 in myocardial cells is closely related to myocardial injury repair (19), and binding of NOTCH1 signaling proteins to Jagged1 reduces fibrotic tissue proliferation, increases microvascular density, and inhibits cardiac endothelial-mesenchymal transition (EMT), thereby preventing myocardial fibrosis (20).