CSF CD4+HLADR+ and CSF/PB CD8+HLADR+ were the most relevant parameters when comparing antibody-negative ALE and Alzheimer’s disease, CSF CD4+HLADR+, PB iMono, CSF CD4+/CD8+ ratio when comparing antibody-negative ALE and FTD (Fig. 5H and I). Here, CD4 is linked to early-onset autosomal dominant Alzheimer disease.