LGI1 and autoimmune encephalitis: Autoimmune limbic encephalitis (ALE) is an inflammatory condition confined to the limbic system that is thought to be due to a dysregulated immune response.1,2 The most common forms of ALE are associated with autoantibodies (AABs) against leucine-rich glioma inactivated 1 (anti-LGI1 ALE) and the 65 kDa isoform of the glutamic acid decarboxylase (anti-GAD65 ALE) while the most common form of autoimmune encephalitis in general is anti-N-methyl-D-aspartate receptor encephalitis.