Parati et al. (2014) found that in healthy volunteers exposed to acute exposure to an altitude of 3,400 m for 3 days, the RAS was partially inhibited. The RAS was completely suppressed at 5,400 m and plasma renin activity, Ang II concentration, and aldosterone levels were significantly reduced. Studies on patients with hypertension have also confirmed that exposure to high-altitude hypoxic conditions suppresses the RAS (Bilo et al., 2015). Moreover, long-term inhibition of the RAS can reduce vascular stiffness and alter the structure and function of blood vessels (Mitchell et al., 2007). This evidence concerns the gene AGT and hypertensive disorder.