The AUC of P85-Ab combined with Rta-IgG and VCA-IgA for predicting the risk of NPC was 0.977 (95% CI: 0.959-0.988), which was greater than the AUC values of Rta-IgG and VCA-IgA (P < 0.01 for all). The gene discussed is CD79A; the disease is nasopharyngeal carcinoma.