T2DM status was found to be significantly associated with TCF7L2 genotypes (absence vs. presence of T2DM: AA/AC/CC = 66.7%/62.8%/52.4% vs. 33.3%/37.2%/47.6%, p for trend = 0.039; Figure 2). This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.