Shortened telomeres are known to activate cellular senescence pathways and inflammatory cascades, potentially contributing to the pathological hallmarks of AD, such as amyloid-beta plaques, tau aggregation, and neurodegeneration (Guo et al., 2022; Müezzinler et al., 2013; Yu and Koh, 2022; López-Otín et al., 2023; Blackburn et al., 2015; Rossiello et al., 2022; Fani et al., 2019; Vaiserman and Krasnienkov, 2021; Yu et al., 2021; Rodríguez-Fernández et al., 2022; Crocco et al., 2023; Wang et al., 2018; Zekry et al., 2010). Here, MAPT is linked to Alzheimer disease.