F8 and COVID-19: In patients with moderate/severe COVID-19 at admission (n=9, 9%), significantly higher levels of CRP, prolonged APTT, decreased FVIII activity, plasminogen activity, FXIII-A2B2 and FXIII-B levels were observed as compared to those with asymptomatic/mild disease (Figures 5A–F), while other markers of coagulation/fibrinolysis did not differ significantly between these groups.