The core mechanism of action of the characteristic metabolite polycyclic polypentadienylacylated acyl resorcinols (PPAPs) from Hypericum perforatum includes selective inhibition of the TNF-α signaling pathway, which alleviates psoriasis-associated pathologic epidermal thickening through modulation of the epidermal cell proliferation cycle, and the compounds provide potential candidate molecules for psoriasis treatment through multi-targeted intervention in the TNF-α-associated signaling network (215). The gene discussed is TNF; the disease is psoriasis.