Given the hyperactivation of PD-1+CD8+ T cells in LN patients and NZB/W F1 mice, we compared PD-1+CD44+CD8+ and PD-1-CD44+CD8+ T cells at pre-disease (12 weeks, 12W) and advanced LN (28 weeks, 28W) stages (Figure 3A). This evidence concerns the gene CD8A and lobular neoplasia.