Similarly, the C-X-C chemokine receptor type 4 (CXCR4), a receptor involved in tumour survival, proliferation, and migration 170-172, has demonstrated improved survival in a GB mouse model using a TRT approach with lipid nanocapsules loaded with rhenium-188 (188Re) targeting CXCR4 173. The gene discussed is CXCR4; the disease is neoplasm.