PI16 and neoplasm: Based on previously reported phenotypic features of fibroblasts 40, we identified 8 distinct subpopulations: matrix CAFs (mCAFs), inflammatory CAFs (iCAFs), interferon response CAFs (ifnCAFs), reticular-like CAFs (rCAFs), tumor-like CAFs (tCAFs), PI16+ CAFs, SMCs, and Pericytes (Figure S5A & S5B).