SPP1 and neoplasm: Angio-TAMs may activate anti-tumor immune responses, and they express high levels of co-stimulatory factors (SPP1), proinflammatory cytokines (IL4I1), and lymphocyte migration-related molecules (ITGB7), LA-TAMs represent an immunosuppressive subset of TAMs, characterized by elevated expression of several negative immunoregulatory factors, including FKBP5 and GPNMB (Figure S4C).