Metastatic dissemination cells also have strong migration inhibitory factor (MIF) signal communication, we performed immuno-histochemistry (IHC) for MIF using independent pancreatic cancer tissue microarray (TMA) cohorts comprising primary tumors of PDAC and liver metastatic lesions., the analysis revealed strong MIF expression in primary tumor tissues, highlighting its critical role in promoting metastasis (Figure S1G & S1H). Here, MIF is linked to familial pancreatic carcinoma.