The processes by which cancer neoantigens are internalized by APCs and subsequently cross-presented to naive CD8+ T cells, and the factors that modulate the activation and function of both naive and primed CD8+ T cells are critical for eliciting effective antitumor immune responses; (2) Tumor cells may adapt compensatory metabolic pathways upon introducing metabolic interventions, leading to acquired resistance 65. The gene discussed is CD8A; the disease is neoplasm.