Advantages of circ-ATP10A include its high diagnostic accuracy (AUC: 0.854), non-invasive detection via serum exosomes, stability in circulation, and prognostic value, making it a promising tool for MM diagnosis, prognosis, and as a therapeutic target to inhibit angiogenesis-driven tumor progression 102.Yanwei Luo et al. identified LRG1, a protein enriched in platelet-derived exosomes, as a key promoter of MM progression. Here, LRG1 is linked to Miyoshi myopathy.