Pirh2, a critical E3 ubiquitin ligase whose role in cardiovascular diseases especially DIC remains poorly understood as far as our knowledge extends, is closely involved in such cellular processes as proliferation, cell cycle regulation, as well as cellular migration and plays a crucial role in different diseases and pathologies including but not limited to various cancers by directing ubiquitinating p53 and promoting its degradation 36. The gene discussed is RCHY1; the disease is cancer.