MYC and neoplasm: We firstly assessed the effects of MYC blockade on tumor immune microenvironment using flow cytometry, and the results showed that EC-siMYC significantly promotes the infiltration of CD3+, CD3+CD8+ T cells and CD11b+F4/80+ macrophages (Figure 8A-B, S9A-C), whereas the CD3+CD4+ T cells, CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells (MDSC) were not obviously affected (Figure S9A-C).