Once internalized, TP-NLC triggered pyroptosis of CC cells through the ROS/caspase-3/GSDME-dependent pathway under 808 nm near-infrared (NIR) laser irradiation, which promoted the maturation of dendritic cells (DCs), facilitated the differentiation and infiltration of CD8+ T cells, activated the adaptive immune response, and augmented the efficacy of anti-PD-1 therapies in CC, thus conferring the regression of both primary and metastatic tumors (Scheme 1B). The gene discussed is CD8A; the disease is metastatic neoplasm.