PDCD1 and neoplasm: Herein, based on the antioxidant and pyroptosis induction effects of GA, we developed a TMTP1-modified nanostructured lipid carrier (TP-NLC) for co-delivery of GA and indocyanine green (ICG) as a potent pyroptosis inducer to enhance tumor immunogenicity for boosting the efficiency of PD-1 blockade.