We observed that KDM2A level in PBMCs is strongly correlated with CAD class (coefficient = 0.15, P = 0.046) and a good predictor for CAD classification (non-obstructive vs. obstructive, AUC = 0.73) (Figure 1G-H), instead of DLX2 and HESX1 (Supplementary figure 1F-G). This evidence concerns the gene DLX2 and coronary artery disorder.