Gene cluster 1, highly expressed in state 3, was associated with lipid-related metabolism (including lipid and atherosclerosis, fluid shear stress and atherosclerosis, cholesterol metabolism, glycolysis, and PPAR signaling) and inflammatory (including antigen processed and presentation, viral protein interactions with cytokine and cytokine receptor, and IL-17 signaling) pathways (Figure 3I). Here, PPARA is linked to atherosclerosis.