In addition, the expression of key mediators of OXPHOS, including NDUFB8, SDHB, UQCRC1, MTCO2 and ATP5A1 were markedly decreased or elevated in HCC cells when SNX17 was knockdown or overexpressed (Figure 4G, Supplementary Figure S8). This evidence concerns the gene ATP5F1A and hepatocellular carcinoma.